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The use of testosterone to treat the symptoms of late-onset hypogonadal men has increased recently due to patient and physician awareness. However, concerns regarding the effect of testosterone on the prostate, in particular any possible effect on the risk of prostate cancer have prompted further research in this regard. Surprisingly, numerous retrospective or small, randomized trials have pointed to a possible improvement in male lower urinary tract symptoms (LUTS) in patients treated with testosterone. The exact mechanism of this improvement is still debated but may have a close relationship to metabolic syndrome. For the clinician, the results of these studies are promising but do not constitute high levels of evidence. A thorough clinical examination (including history, examination and laboratory testing of testosterone) should be undertaken before considering the diagnosis of late-onset hypogonadism or instigating treatment for it. Warnings still remain on the testosterone supplement product labels regarding the risk of urinary retention and worsening LUTS, and these should be explained to patients. testosterone.

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To determine the degree of transparency of health insurance policies regarding coverage of male sexual health conditions, we examined the publicly available policy coverage documents of the largest U.S. medical insurance plans. testosterone.

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A 12-week low-calorie diet and an isocaloric diet combined with metformin produced comparable and significant weight loss with improvements in body composition. Both interventions did not significantly affect FSH, LH and DHEA sulfate serum concentrations, only a trend towards an E2 increase and a T decrease was observed, stronger in LC group. The significant correlations shown between the changes in anthropometric and body composition parameters and T serum levels in women treated with a low-calorie diet alone show the beneficial effect of a lifestyle intervention on the sex hormone in obese premenopausal women. testosterone.

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A 12-week observational, longitudinal study of hypogonadal men was conducted. Participants completed the HIS-Q every 2 weeks. Blood samples were collected to evaluate testosterone levels. Participants also completed the Aging Male’s Symptoms Scale, the International Index of Erectile Function, the Short Form-12 Health Survey, and the Patient-Reported Outcomes Measurement Information System Sexual Activity, Satisfaction with Sex Life, Sleep Disturbance, and Applied Cognition Scales (at baseline and weeks 6 and 12). Clinicians completed the Clinical Global Impression of Severity and Change measurements and a clinical form. testosterone.

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We used data from a representative sample of 953 subjects ≥65 years who participated in the InCHIANTI (Invecchiare in Chianti) Study and were not on growth hormone (GH) or erythropoietin therapy and were not diagnosed with hematologic malignancies or other cancers. Anemia was defined according to the World Health Organization (WHO) criteria by Hb level ≤13 g/dL in males and ≤12 g/dL in females. Backward multiple regression analyses including age, IGF binding protein (IGFBP)-3, testosterone, comorbidities, inflammatory markers, and anemia-related measures were used to address the relationship between IGF-1 and Hb and between IGF-1 and anemia in both sexes. testosterone.

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Testosterone (TES) and other androgens exert a direct vasorelaxing action on the vasculature in vitro that is structurally specific and independent of cytosolic androgen receptor (AR). The effects of intravenous androgen infusions on mean arterial blood pressure (BP) and heart rate (HR) were determined in conscious, unrestrained, chronically catheterized, ganglionically blocked (hexamethonium, HEX; 30 mg/kg ip) male Sprague-Dawley (SD) and testicular-feminized male (Tfm; AR-deficient) rats, 16-20 wk of age. BP and HR were recorded at baseline and with increasing doses of androgens (0.375-6.00 μmol·kg(-1)·min(-1) iv; 10 min/dose). Data are expressed as means ± SE (n = 5-8 rats/group). In SD rats, baseline BP and HR averaged 103 ± 4 mmHg and 353 ± 12 beats/min (bpm). TES produced a dose-dependent reduction in BP to a low of 87 ± 4 mmHg (Δ16%), while HR was unchanged (354 ± 14 bpm). Neither BP (109 ± 3 mmHg) nor HR (395 ± 13 bpm) were altered by vehicle (10% EtOH in 0.9% saline; 0.15 ml·kg(-1)·min(-1), iv). In Tfm, TES produced a similar reduction in BP (99 ± 3 to 86 ± 3 mmHg, Δ13%); HR was unchanged (369 ± 18 bpm). In SD, 5β-dihydrotestosterone (genomically inactive metabolite) produced a greater reduction in BP than TES (102 ± 2 to 79 ± 2 mmHg, Δ23%); HR was unchanged (361 ± 9). A 20-μg iv bolus of sodium nitroprusside in both SD and Tfm rats reduced BP 30-40 mmHg, while HR was unchanged, confirming blockade by HEX. Pretreatment of SD rats with neuronal nitric oxide synthase (nNOS) inhibitor (S-methyl-thiocitrulline, SMTC; 20 μg·kg(-1)·min(-1) × 30 min) abolished the hypotensive effects of TES infusion on BP (104 ± 2 vs. 101 ± 2 mmHg) and HR (326 ± 11 vs. 324 ± 8 bpm). These data suggest the systemic hypotensive effect of TES and other androgens involves a direct vasodilatory action on the peripheral vasculature which, like the effect observed in isolated arteries, is structurally specific and AR-independent, and involves activation of nNOS. testosterone.

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  • http://www.myspace.com/smojface Miles

    I adore my “cinematic” jazzy, hip-hop/electro stuff. adore jaga (it’s currently in my car AND laptop) and remember seeing the Cinematic Orchaestra for the first time!

    Had a gig last night – The Hub. Kinda jazz vs. metal. 3 players, drummer, alto sax, and electric bass. Never seen so many effects in my life – 4 for the saxist, and.. about 10/12 for the bassist. Well worth seeing!

  • http://www.myspace.com/smojface Miles

    I adore my “cinematic” jazzy, hip-hop/electro stuff. adore jaga (it’s currently in my car AND laptop) and remember seeing the Cinematic Orchaestra for the first time!

    Had a gig last night – The Hub. Kinda jazz vs. metal. 3 players, drummer, alto sax, and electric bass. Never seen so many effects in my life – 4 for the saxist, and.. about 10/12 for the bassist. Well worth seeing!

  • http://www.fizikz.com/ jeej

    Jazz versus metal? I’m not really a fan of metal, but your description makes it sound very interesting! Glad you had a good time.

    What did you think of this track, by the way?

  • http://www.fizikz.com/ jeej

    Jazz versus metal? I’m not really a fan of metal, but your description makes it sound very interesting! Glad you had a good time.

    What did you think of this track, by the way?

  • http://www.myspace.com/smojface Miles

    Sadly, I’m at work (at a school) so I’l have to wait till lunchtime to listen, butI’ll let you know. Sounds promising given your description!

  • http://www.myspace.com/smojface Miles

    Sadly, I’m at work (at a school) so I’l have to wait till lunchtime to listen, butI’ll let you know. Sounds promising given your description!

  • http://www.fizikz.com/ jeej

    That’s cool Miles, I look forward to hearing your thoughts. 🙂

  • http://www.fizikz.com/ jeej

    That’s cool Miles, I look forward to hearing your thoughts. 🙂

  • http://www.myspace.com/mikebandoni MIke Bandoni

    Good blog sir! Keep it up, all the music folks on myspace should salute you and could probably do with as much hype as they can get! I will keep reading….

  • http://www.myspace.com/mikebandoni MIke Bandoni

    Good blog sir! Keep it up, all the music folks on myspace should salute you and could probably do with as much hype as they can get! I will keep reading….

  • http://www.fizikz.com/ jeej

    Cheers Mike, I appreciate your kind words.

    Hope you are well?

  • http://www.fizikz.com/ jeej

    Cheers Mike, I appreciate your kind words.

    Hope you are well?

  • http://www.myspace.com/wish_ka wishka

    Glad to hear you like Brodway Project, looking forward to your new posts, keep it up ! 🙂

    Cheers

  • http://www.myspace.com/wish_ka wishka

    Glad to hear you like Brodway Project, looking forward to your new posts, keep it up ! 🙂

    Cheers

  • http://www.fizikz.com/ jeej

    Thanks matey!

  • http://www.fizikz.com/ jeej

    Thanks matey!

  • http://eashfa.wordpress.com/ Linda

    Good golly gosh. Off the chain posts, nice n sleek, I know I tend to be more messy 😉

  • http://eashfa.wordpress.com/ Linda

    Good golly gosh. Off the chain posts, nice n sleek, I know I tend to be more messy 😉

  • http://www.fizikz.com/ jeej

    Thanks Linda, but only time will tell if I can keep it up!!!

    Did you see my last.fm journal?… http://www.last.fm/user/jeej/journal/2006/05/18/137880/

  • http://www.fizikz.com/ jeej

    Thanks Linda, but only time will tell if I can keep it up!!!

    Did you see my last.fm journal?… http://www.last.fm/user/jeej/journal/2006/05/18/137880/

  • aha

    So this is what all children were waiting for ;P Gav’s pick of the week 😉 Broadway Project is great indeed 😉 Wishka – thanks for that recommendation 😉
    And you, young Brit, keep it up!

  • http://yeah,youwish aha

    So this is what all children were waiting for ;P Gav’s pick of the week 😉 Broadway Project is great indeed 😉 Wishka – thanks for that recommendation 😉
    And you, young Brit, keep it up!

  • http://www.newmils.co.uk/ Daymo

    t’is a very interesting song.

  • http://www.newmils.co.uk Daymo

    t’is a very interesting song.

  • http://www.fizikz.com/ jeej

    Ha ha, thanks Joanna!

  • http://www.fizikz.com/ jeej

    Ha ha, thanks Joanna!

  • Aaron

    I found the Compassion a little hard to get into. Yes, yes I know I can happily listen to autechre for days a time in a state of blissful joy, but whatever. This track, however, is excellent. I love how it stops and starts at the beginning giving a sense of anticipation, and how it climaxes and then cools down with the gentle guitars and the self-help-esq vocals. Excellent,

  • Aaron

    I found the Compassion a little hard to get into. Yes, yes I know I can happily listen to autechre for days a time in a state of blissful joy, but whatever. This track, however, is excellent. I love how it stops and starts at the beginning giving a sense of anticipation, and how it climaxes and then cools down with the gentle guitars and the self-help-esq vocals. Excellent,

  • Aaron

    Did I mention the FLUTES at the start? I’m a big fan of FLUTES. A big fan. A big, big fan.

  • Aaron

    Did I mention the FLUTES at the start? I’m a big fan of FLUTES. A big fan. A big, big fan.

  • http://dreamstress.deviantart.com/ Heather

    this was like having an orgasm on a water bed. so very lush and fluid. you know how much i appreciate that in music. Dammit, you still need to listen to Dirty Three’s Ocean Songs

  • http://dreamstress.deviantart.com Heather

    this was like having an orgasm on a water bed. so very lush and fluid. you know how much i appreciate that in music. Dammit, you still need to listen to Dirty Three’s Ocean Songs